MovDisordV3, Main, Exploration, bibRecord, 004D38

GPi Firing rate modification during beginning‐of‐dose motor deterioration following acute administration of apomorphine

Identifieur interne : 004D38 ( Main/Exploration ); précédent : 004D37; suivant : 004D39

GPi Firing rate modification during beginning‐of‐dose motor deterioration following acute administration of apomorphine

Auteurs : Marcelo Merello [Argentine] ; Andrew Lees (neurologue) [Royaume-Uni] ; Jorge Balej [Argentine] ; Angel Cammarota [Argentine] ; Ram N Leiguarda [Argentine]

Source :

Movement Disorders [ 0885-3185 ] ; 1999-05.

RBID : ISTEX:20E0C15F26CB176D16DF271ABE53529D75B00A56

Descripteurs français

Pascal (Inist)
- Aggravation, Agoniste, Antiparkinsonien, Apomorphine, Effet secondaire, Electrodiagnostic, Epreuve pharmacologique, Etude cas, Installation traitement, Microélectrode, Mâle, Mécanisme action, Pallidotomie, Pallidum, Parkinson maladie, Peropératoire, Personne âgée, Récepteur dopaminergique, Stimulant dopaminergique, Stéréotaxie, Toxicité, Trouble moteur.
Wicri :
- topic : Personne âgée.

English descriptors

KwdEn :
- Action Potentials (drug effects), Action Potentials (physiology), Aggravation, Agonist, Antiparkinson agent, Apomorphine, Apomorphine (pharmacology), Apomorphine (therapeutic use), Basal Ganglia (drug effects), Basal ganglia, Beginning‐of‐dose motor deterioration, Case study, Dopamine Agonists (pharmacology), Dopamine Agonists (therapeutic use), Dopamine agonist, Dopamine receptor, Dose-Response Relationship, Drug, Elderly, Electrodiagnosis, GPi, Globus Pallidus (drug effects), Globus Pallidus (surgery), Humans, Intraoperative, Male, Mechanism of action, Microelectrode, Middle Aged, Monitoring, Intraoperative, Motor system disorder, Neurons (drug effects), Pallidotomy, Pallidum, Parkinson Disease (drug therapy), Parkinson disease, Pharmacologic test, Psychomotor Performance (drug effects), Secondary effect, Stereotaxia, Stereotaxic Techniques, Thalamus (drug effects), Time Factors, Toxicity, Treatment installation.
MESH :
- chemical , pharmacology : Apomorphine, Dopamine Agonists.
- drug effects : Action Potentials, Basal Ganglia, Globus Pallidus, Neurons, Psychomotor Performance, Thalamus.
- drug therapy : Parkinson Disease.
- physiology : Action Potentials.
- surgery : Globus Pallidus.
- chemical , therapeutic use : Apomorphine, Dopamine Agonists.
- Dose-Response Relationship, Drug, Humans, Male, Middle Aged, Monitoring, Intraoperative, Stereotaxic Techniques, Time Factors.

Abstract

We present a patient with clinically evident beginning‐of‐dose motor deterioration who had undergone posteroventral pallidotomy. This patient underwent an intrasurgical apomorphine test followed by single cell recording of the internal globus pallidus (GPi) to determine changes in GPi firing rate during the occurrence of such phenomenon. A significant increase in GPi firing rate coincident with worsening of patient disabilities prior to improvement was found. This finding suggests that beginning‐of‐dose motor deterioration may be mediated by enhanced thalamic inhibition.

Url:

https://api.istex.fr/document/20E0C15F26CB176D16DF271ABE53529D75B00A56/fulltext/pdf

DOI: 10.1002/1531-8257(199905)14:3<481::AID-MDS1015>3.0.CO;2-H

Affiliations:

Le document en format XML

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<term>Aggravation</term>
<term>Agonist</term>
<term>Antiparkinson agent</term>
<term>Apomorphine</term>
<term>Apomorphine (pharmacology)</term>
<term>Apomorphine (therapeutic use)</term>
<term>Basal Ganglia (drug effects)</term>
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<term>Beginning‐of‐dose motor deterioration</term>
<term>Case study</term>
<term>Dopamine Agonists (pharmacology)</term>
<term>Dopamine Agonists (therapeutic use)</term>
<term>Dopamine agonist</term>
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<term>Electrodiagnosis</term>
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<term>Globus Pallidus (surgery)</term>
<term>Humans</term>
<term>Intraoperative</term>
<term>Male</term>
<term>Mechanism of action</term>
<term>Microelectrode</term>
<term>Middle Aged</term>
<term>Monitoring, Intraoperative</term>
<term>Motor system disorder</term>
<term>Neurons (drug effects)</term>
<term>Pallidotomy</term>
<term>Pallidum</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson disease</term>
<term>Pharmacologic test</term>
<term>Psychomotor Performance (drug effects)</term>
<term>Secondary effect</term>
<term>Stereotaxia</term>
<term>Stereotaxic Techniques</term>
<term>Thalamus (drug effects)</term>
<term>Time Factors</term>
<term>Toxicity</term>
<term>Treatment installation</term>
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<term>Dopamine Agonists</term>
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<term>Basal Ganglia</term>
<term>Globus Pallidus</term>
<term>Neurons</term>
<term>Psychomotor Performance</term>
<term>Thalamus</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Action Potentials</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Apomorphine</term>
<term>Dopamine Agonists</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Dose-Response Relationship, Drug</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Monitoring, Intraoperative</term>
<term>Stereotaxic Techniques</term>
<term>Time Factors</term>
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<term>Agoniste</term>
<term>Antiparkinsonien</term>
<term>Apomorphine</term>
<term>Effet secondaire</term>
<term>Electrodiagnostic</term>
<term>Epreuve pharmacologique</term>
<term>Etude cas</term>
<term>Installation traitement</term>
<term>Microélectrode</term>
<term>Mâle</term>
<term>Mécanisme action</term>
<term>Pallidotomie</term>
<term>Pallidum</term>
<term>Parkinson maladie</term>
<term>Peropératoire</term>
<term>Personne âgée</term>
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<term>Stimulant dopaminergique</term>
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<front><div type="abstract" xml:lang="en">We present a patient with clinically evident beginning‐of‐dose motor deterioration who had undergone posteroventral pallidotomy. This patient underwent an intrasurgical apomorphine test followed by single cell recording of the internal globus pallidus (GPi) to determine changes in GPi firing rate during the occurrence of such phenomenon. A significant increase in GPi firing rate coincident with worsening of patient disabilities prior to improvement was found. This finding suggests that beginning‐of‐dose motor deterioration may be mediated by enhanced thalamic inhibition.</div>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
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Movement Disorders (revue)

GPi Firing rate modification during beginning‐of‐dose motor deterioration following acute administration of apomorphine

GPi Firing rate modification during beginning‐of‐dose motor deterioration following acute administration of apomorphine

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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	Movement Disorders (revue)
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